Clinical outcomes of amyloid and tau markers according to vascular markers

Background Alzheimer’s disease (AD) is characterized by amyloid beta (Aβ) aggregation [A] and tau reflecting neurofibrillary tangles [T]. These AD markers lead to neurodegeneration [N] cognitive impairments. Recently, the ATN research framework of was presented National Institute on Aging Association. Cerebral small vessel (CSVD, [V]), which one most important cause impairments, has an additive or synergistic effect impairments with markers. In present study, we investigated frequency ATV abnormalities in participants varying degree CSVD We also determined whether might synergistically affect decline Method consecutively recruited 195 subjects (105 AD-related impairment subjects, 86 subcortical vascular subjects) from Samsung Medical Center. [T] positivities were cut-off values Aβ uptakes PET using iterative outlier methods. [V] assessed presence severe white matter hyperintensity. All underwent neuropsychological tests including Mini-Mental State Exam (MMSE) clinical dementia rating-sum boxes (CDR-SOB). A linear mixed model used compare changes over time. Result The number A-T-, A+T-, A+T+ groups 16 (15.1%), 29 (27.4%), 56 (52.8%) V- group; 46 (51.7%), 33 (37.1%), 8 (9.0%) V+ group. effects analysis showed that A+/T+ associated worse decline, its impact higher group than (Figure). Conclusion Our findings suggested there interactive decline. demonstrate importance factor management patients suggest useful predicting practice.